Scientific Evidence
Research Studies (animal, bench, or in-vitro)
The Benefits of 45S5 Compared to S53P4
Dissolution of Glass–Ceramic Scafolds of Bioactive Glasses 45S5 and S53P4
Laura Aalto-Setälä, Minna Siekkinen, Nina Lindfors, Leena Hupa
Angiogenic potential
Angiogenesis induced by degradation products of hyaluronic acid
West, DC Hampson
Effect of Bioactive Glasses on Angiogenesis: A Review of In Vitro and In Vivo Evidences
Alejandro A. Gorustovich, Judith A. Roether, and Aldo R. Boccaccini
Antimicrobial properties
Recent Evidence on Bioactive Glass Antimicrobial and Antibiofilm Activity: A Mini-Review
Lorenzo Drago, Marco Toscano, Marta Bottagisio
Efficacy of Irradiated Bioactive Glass 45S5 on Attenuation of Microbial Growth and Eradication of Biofilm from AISI 316 L Discs: In-vitro Study
S. Y. El-Tablawy, Wesam M Abd-Allah, Eman Araby
Antimicrobial Properties of 45S5 Bioactive Glass Particulate Antimicrobial Properties of 45S5 Bioactive Glass Particulate
David M. Gaisser David M. Gaisser, David C. Greenspan
Antibacterial effects and dissolution behavior of six bioactive glasses
Di Zhang, Outi Leppäranta, Eveliina Munukka, Heimo Ylänen, Matti K. Viljanen, Erkki Eerola, Mikko Hupa
Comparison of Reactions of Bioactive Glasses in Different Aqueous Solutions
Susanne Fagerlund, Leena Hupa, Mikko Hupa
Do bioactive glasses convey a disinfecting mechanism beyond a mere increase in pH?
M. Gubler, T. J. Brunner, M. Zehnder, T. Waltimo, B. Sener, W. J. Stark
Antimicrobial Effect of Nanometric Bioactive Glass 45S5
T. Waltimo, T.J. Brunner, […], and M. Zehnder
Antibacterial activity of particulate Bioglass against supra- and subgingival bacteria
I Allan, H Newman, M Wilson
Highly Osteoconductive material
Effect of Bioactive Glasses on Angiogenesis: A Review of In Vitro and In Vivo Evidences
Alejandro A. Gorustovich, Judith A. Roether, and Aldo R. Boccaccini
Stimulation of osteoinduction in bone wound healing by high-molecular hyaluronic acid
T. Sasaki, C. Watanabe
Osteostimulation
The Genetic Basis for Osteogenesis Stimulation
Hench, L. & Gaisser, D. M.
A Genetic Basis for Design of Biomaterials For In Situ Tissue Regeneration
Larry L. Hench, Julia M. Polak
Ionic Products of Bioactive Glass Dissolution Increase Proliferation of Human Osteoblasts and Induce Insulin-like Growth Factor II mRNA Expression and Protein Synthesis
Ioannis D. Xynos, Alasdair J. Edgar, Lee D. K. Buttery, Larry L. Hench, Julia M. Polak
Bioglass 45S5 Stimulates Osteoblast Turnover and Enhances Bone Formation In Vitro: Implications and Applications for Bone Tissue Engineering
I. D. Xynos, M. V. J. Hukkanen, J. J. Batten, L. D. Buttery, L. L. Hench, J. M. Polak
Osteostimulation of bioglass
HU Yong-cheng, ZHONG Ji-pin
The effect of NovaBone combined with autologous iliac in the acetabular osteotomy of children with developmental dislocation of the hip
Xiong ZHAO; Yishan MA; Qingda LU; Wei LEI; Qiang JIE
Superior Resorption Profile
In vivo absorbability of 45S5 Bioglass
David M. Gaisser
Ionic Dissolution Products of NovaBone Promote Osteoblastic Proliferation via Influences on the Cell Cycle
Z QIU, H YANG, J WU, L WEI AND J LI
Resorption profile
D.Gaisser, D. Wheeler
Disclaimer
The authors, editors, and publisher have taken great care to ensure that the drug, device, and material selections and applications provided in this publication align with prevailing recommendations and practices at the time of publication.
Nevertheless, in light of ongoing research, evolving government regulations, and the constant influx of information pertaining to surgical procedures, grafting materials, and techniques, we strongly encourage readers to consult the package insert before employing any discussed material. Be vigilant for any alterations in indications and additional warnings and precautions, especially when dealing with newly introduced or rarely utilized agents.
It is crucial for readers to recognize the potential risks associated with incorporating unfamiliar techniques and procedures into their practices. Treatment decisions ultimately rest with individual surgeons, who exercise their professional judgment in each unique situation. We recommend that readers seek professional advice from their colleagues and advisors.
The Company cannot guarantee the accuracy, comprehensiveness, or timeliness of the information presented and disclaims responsibility for any claims, injuries, damages, or losses stemming from the use of or reliance on the material presented or techniques demonstrated. Healthcare professionals or any other individuals may make such claims.